Oral Administration of Recombinant Adeno-associated Virus-mediated Bone Morphogenetic Protein-7 Suppresses CCI sub(4)-induced Hepatic Fibrosis in Mice

Fibrogenesis and hepatocyte degeneration are the main pathological processes in chronic liver diseases. Transforming growth factor- beta 1 (TGF- beta 1) is the key profibrotic cytokine in hepatic fibrosis. Bone morphogenetic protein-7 (BMP-7) is a potent antagonist of TGF- beta 1 and an antifibrotic...

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Bibliographic Details
Published inMolecular therapy Vol. 20; no. 11; pp. 2043 - 2051
Main Authors Hao, Zhi-Ming, Cai, Min, Lv, Yi-Fei, Huang, Yan-Hua, Li, Hong-Hong
Format Journal Article
LanguageEnglish
Published 01.11.2012
Subjects
Adeno-associated virus
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ISSN1525-0016
1525-0024
DOI10.1038/mt.2012.148

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