Transfersomes: Novel vesicular carriers for enhanced transdermal drug delivery of Candesartan cilexetil

• Published in: Indian journal of research in pharmacy and biotechnology Vol. 2; no. 5; p. 1405
• Main Authors: Kalyani, V, Babu, M Kishore
• Format: Journal Article
• Language: English
• Published: 01.09.2014
• ISSN: 2321-5674; 2320-3471

The aim of this research activity is to formulate Soyalecithin based transfersomal nanoparticles for percutaneous administration of Candesartan cilexetil for better management against cardiovascular diseases. The IR peaks obtained for the physical mixture of Candesartan cilexetil was mostly identical with the pure sample of Candesartan cilexetil indicating their compatibility. Candesartan cilexetil transfersomes were formulated by employing thin film hydration followed by high speed homogenization technique. Drug entrapment efficiency of optimized formulation "F3" was found to be 50.72%. In-vitro diffusion studies of all the formulations revealed that, the Candesartan cilexetil transfersomes followed first order kinetics, ascertaining Peppas mechanism. Application of Korsmeyer-Peppas equation to the data of the formulations revealed that mechanism of Candesartan cilexetil transfersomes was governed by predominant Non-Fickian diffusion. Based on the satisfied release studies of all the formulations, F3 was confined to be the optimized formulation. The particle size of the formulation F3 was found to be 194.4nm indicating that the formulation was well within the nanosomal range.