Analysis of functional selectivity through G protein-dependent and -independent signaling pathways at the adrenergic alpha 2C receptor

• Published in: Brain research bulletin Vol. 107; pp. 89 - 101
• Main Authors: Kurko, Dalma, Kapui, Zoltan, Nagy, Jozsef, Lendvai, Balazs, Kolok, Sandor
• Format: Journal Article
• Language: English
• Published: 01.08.2014

Although G protein-coupled receptors (GPCRs) are traditionally categorized as Gs-, Gq-, or Gi/o-coupled, their signaling is regulated by multiple mechanisms. GPCRs can couple to several effector pathways, having the capacity to interact not only with more than one G protein subtype but also with alt...