IL-6 mediates the effects of IL-1 or TNF, but not PTHrP or 1,25(OH) sub(2)D sub(3), on osteoclast-like cell formation in normal human bone marrow cultures

• Published in: Journal of bone and mineral research Vol. 13; no. 3; pp. 393 - 399
• Main Authors: Devlin, R D, Reddy, S V, Savino, R, Ciliberto, G, Roodman, G D
• Format: Journal Article
• Language: English
• Published: 01.03.1998

A potent interleukin-6 (IL-6) antagonist (Sant 5), which binds tightly to the IL-6 alpha receptor but has impaired gp130 heterodimerization, has been developed recently by site-directed mutagenesis of human IL-6. We report here that Sant 5 inhibits IL-6-stimulated osteoclast-like multinucleated cell...