Physical analysis of the region deleted in the t super(w18) allele of the mouse tcl-4 complementation group

We have generated a YAC contig of at least 3.3 Mb from the proximal region of In(17)4 of mouse chromosome 17. This region corresponds to DNA lost in the gastrulation mutant t super(w18), which belongs to the tcl-4 complementation group. Our most proximal and distal probes lie within the deletion-3.3...

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Published inGenomics (San Diego, Calif.) Vol. 36; no. 1; pp. 39 - 46
Main Authors Barclay, J, King, T F, Crossley, PH, Barnard, R C, Larin, Z, Lehrach, H, Little, PFR
Format Journal Article
LanguageEnglish
Published 01.08.1996
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Summary:We have generated a YAC contig of at least 3.3 Mb from the proximal region of In(17)4 of mouse chromosome 17. This region corresponds to DNA lost in the gastrulation mutant t super(w18), which belongs to the tcl-4 complementation group. Our most proximal and distal probes lie within the deletion-3.3 Mb apart-indicating that we have not cloned the entire region. The deleted region is contained in a genetic interval of less than 1 cM, suggesting that some suppression of recombination must occur.
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ISSN:0888-7543