Peptides containing glutamine repeats as substrates for transglutaminase-catalyzed cross-linking: Relevance to diseases of the nervous system

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 93; no. 26; pp. 14580 - 14585
• Main Authors: Kahlem, P, Terre, C, Green, H, Djian, P
• Format: Journal Article
• Language: English
• Published: 01.12.1996

Many proteins contain reiterated glutamine residues, but polyglutamine of excessive length may result in human disease by conferring new properties on the protein containing it. One established property of a glutamine residue, depending on the nature of the flanking residues, is its ability to act a...