Sp1 binding plays a critical role in Erb-B2- and v-ras-mediated downregulation of alpha sub(2)-integrin expression in human mammary epithelial cells

• Published in: Molecular and cellular biology Vol. 16; no. 11; pp. 6178 - 6189
• Main Authors: Ye, Jianping, Xu, Ruo Hui, Taylor-Papadimitriou, J, Pitha, P M
• Format: Journal Article
• Language: English
• Published: 01.01.1996

The human alpha sub(2)-integrin gene is transcriptionally downregulated in a nontumorigenic human mammary epithelial cell line, MTSV1-7, and its clonal variant HB2, overexpressing the Erb-B2 oncogene. In this study, we have used deletion mutations within the alpha sub(2)-integrin promoter inserted 5...