Morphine-induced antinociception in the rat: Supra-additive interactions with imidazoline I sub(2 receptor ligands)

• Published in: European journal of pharmacology Vol. 669; no. 1-3; pp. 59 - 65
• Main Authors: Li, Jun-Xu, Zhang, Yanan, Winter, Jerrold C
• Format: Journal Article
• Language: English
• Published: 01.11.2011

Pain remains a significant clinical challenge and currently available analgesics are not adequate to meet clinical needs. Emerging evidence suggests the role of imidazoline I sub(2 receptors in pain modulation primarily from studies of the non-selective imidazoline receptor ligand, agmatine. However...