Kinetics of phospholipase A sub(2), arachidonic acid, and eicosanoid appearance in mouse zymosan peritonitis

Intraperitoneal injection of zymosan into mice induces a peritonitis characterized by cellular influx, plasma leakage and the appearance of arachidonic acid (AA) metabolites. We report that zymosan injection also stimulates the accumulation of AA, docosahexaenoic acid, linoleic acid, and phospholipa...

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Published inThe Journal of immunology (1950) Vol. 144; no. 7; pp. 2671 - 2677
Main Authors Lundy, SR, Dowling, R L, Stevens, T M, Kerr, J S, Mackin, WM, Gans, K R
Format Journal Article
LanguageEnglish
Published 01.01.1990
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Abstract Intraperitoneal injection of zymosan into mice induces a peritonitis characterized by cellular influx, plasma leakage and the appearance of arachidonic acid (AA) metabolites. We report that zymosan injection also stimulates the accumulation of AA, docosahexaenoic acid, linoleic acid, and phospholipase A sub(2) (PLA sub(2)) activity. The amount of the unsaturated fatty acids (UnFa) varies both with the zymosan dose and time. The results suggest that a significant portion of the UnFa found in the peritoneal cavity of zymosan-injected mice originates from the plasma. PLA sub(2) activity at the early time points (5 to 15 min) may also contribute to the levels of UnFA via hydrolysis of tissue and/or cellular phospholipids.
AbstractList Intraperitoneal injection of zymosan into mice induces a peritonitis characterized by cellular influx, plasma leakage and the appearance of arachidonic acid (AA) metabolites. We report that zymosan injection also stimulates the accumulation of AA, docosahexaenoic acid, linoleic acid, and phospholipase A sub(2) (PLA sub(2)) activity. The amount of the unsaturated fatty acids (UnFa) varies both with the zymosan dose and time. The results suggest that a significant portion of the UnFa found in the peritoneal cavity of zymosan-injected mice originates from the plasma. PLA sub(2) activity at the early time points (5 to 15 min) may also contribute to the levels of UnFA via hydrolysis of tissue and/or cellular phospholipids.
Author Kerr, J S
Lundy, SR
Mackin, WM
Gans, K R
Dowling, R L
Stevens, T M
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