AgATP-coated liposomes: SERS traceable delivery vehicles for living cells

A liposome-Ag nanohybrid has been demonstrated as a SERS traceable intracellular drug nanocarrier. Liposomes have been introduced for their special qualities in drug delivery systems. In essence, 4-aminothiophenol (4ATP) tagged Ag nanoparticles (AgATP) were adsorbed onto the surfaces of liposomes vi...

Full description

Saved in:
Bibliographic Details
Published inNanoscale Vol. 6; no. 14; pp. 8155 - 8161
Main Authors Zhu, Dan, Wang, Zhuyuan, Zong, Shenfei, Chen, Hui, Wu, Xin, Pei, Yuwei, Chen, Peng, Ma, Xueqin, Cui, Yiping
Format Journal Article
LanguageEnglish
Published 01.06.2014
Subjects
Carriers
Drug delivery systems
Drugs
Fluorescence
Liposomes
Nanoparticles
Nanostructure
Vehicles
Online AccessGet full text

Cover

More Information
Summary:A liposome-Ag nanohybrid has been demonstrated as a SERS traceable intracellular drug nanocarrier. Liposomes have been introduced for their special qualities in drug delivery systems. In essence, 4-aminothiophenol (4ATP) tagged Ag nanoparticles (AgATP) were adsorbed onto the surfaces of liposomes viaelectrostatic interactions, in which 4ATP was used as a SERS reporter. In such a nanohybrid, the locations of the carrier can be tracked by SERS signals while those of the drugs can be monitored through their fluorescence, allowing the simultaneous investigation of the intracellular distribution of both the carriers and the drugs. Our experimental results suggest that the reported liposomal system has substantial potential for intracellular drug delivery.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-1
ISSN:2040-3364
2040-3372
DOI:10.1039/c4nr00557k