Antagonizing the alpha 4 beta 1 Integrin, but Not alpha 4 beta 7, Inhibits Leukocytic Infiltration of the Central Nervous System in Rhesus Monkey Experimental Autoimmune Encephalomyelitis

• Published in: The Journal of immunology (1950) Vol. 190; no. 5; pp. 1961 - 1973
• Main Authors: Haanstra, Krista G, Hofman, Sam O, Lopes Estevao, Dave M, Blezer, Erwin LA, Bauer, Jan, Yang, Li-Li, Wyant, Tim, Csizmadia, Vilmos, 't Hart, Bert A, Fedyk, Eric R
• Format: Journal Article
• Language: English
• Published: 01.03.2013
• Subjects: Macaca mulatta; Primates

The immune system is characterized by the preferential migration of lymphocytes through specific tissues (i.e., tissue tropism). Tissue tropism is mediated, in part, by the alpha 4 integrins expressed by T lymphocytes. The alpha 4 beta 1 integrin mediates migration of memory T lymphocytes into the C...