A beta 1-42-RAGE Interaction Disrupts Tight Junctions of the Blood-Brain Barrier Via Ca2+-Calcineurin Signaling

The blood-brain barrier (BBB), which is formed by adherens and tight junctions (TJs) of endothelial cells, maintains homeostasis of the brain. Disrupted intracellular Ca2+ homeostasis and breakdown of the BBB have been implicated in the pathogenesis of Alzheimer's disease (AD). The receptor for...

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Bibliographic Details
Published inThe Journal of neuroscience Vol. 32; no. 26; pp. 8845 - 8854
Main Authors Kook, Sun-Young, Hong, Hyun Seok, Moon, Minho, Ha, Chang Man, Chang, Sunghoe, Mook-Jung, Inhee
Format Journal Article
LanguageEnglish
Published 27.06.2012
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