Inhibition of alpha -l-fucosidase by derivatives of deoxyfuconojirimycin and deoxymannojirimycin
Deoxyfuconojirimycin (1,5-dideoxy-1,5-imino-L-fucitol) is a potent, specific and competitive inhibitor (K sub(i) 1 x 10 super(-8) M) of human liver alpha -L-fucosidase (EC 3.2.1.51). Six structural analogues of this compound were synthesized and tested for their ability to inhibit alpha -L-fucosidas...
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| Published in | Biochemical journal Vol. 256; no. 1; pp. 277 - 282 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.01.1990
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Deoxyfuconojirimycin (1,5-dideoxy-1,5-imino-L-fucitol) is a potent, specific and competitive inhibitor (K sub(i) 1 x 10 super(-8) M) of human liver alpha -L-fucosidase (EC 3.2.1.51). Six structural analogues of this compound were synthesized and tested for their ability to inhibit alpha -L-fucosidase and other human liver glycosidases. It is concluded that the minimum structural requirement for inhibition of alpha -L-fucosidase is the correct configuration of the hydroxy groups at the piperidine ring carbon atoms 2, 3 and 4. |
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| AbstractList | Deoxyfuconojirimycin (1,5-dideoxy-1,5-imino-L-fucitol) is a potent, specific and competitive inhibitor (K sub(i) 1 x 10 super(-8) M) of human liver alpha -L-fucosidase (EC 3.2.1.51). Six structural analogues of this compound were synthesized and tested for their ability to inhibit alpha -L-fucosidase and other human liver glycosidases. It is concluded that the minimum structural requirement for inhibition of alpha -L-fucosidase is the correct configuration of the hydroxy groups at the piperidine ring carbon atoms 2, 3 and 4. |
| Author | Jacob, G S Baines, S Fleet, G Namgoong, S K Winchester, B Barker, C |
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| Title | Inhibition of alpha -l-fucosidase by derivatives of deoxyfuconojirimycin and deoxymannojirimycin |
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