Radiosynthesis and Biological Evaluation of N-[18F]Labeled Glutamic Acid as a Tumor Metabolic Imaging Tracer: e93262

• Published in: PloS one Vol. 9; no. 3
• Main Authors: Hu, Kongzhen, Du, Kan, Tang, Ganghua, Yao, Shaobo, Wang, Hongliang, Liang, Xiang, Yao, Baoguo, Huang, Tingting, Zang, Linquan
• Format: Journal Article
• Language: English
• Published: 01.03.2014

We have previously reported that N-(2-[18F]fluoropropionyl)-L-methionine ([18F]FPMET) selectively accumulates in tumors. However, due to the poor pharmacokinetics of [18F]FPMET in vivo, the potential clinical translation of this observation is hampered. In this study, we rationally designed and synt...