Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD sub(2) receptors CRTH2 and DP

• Published in: Bioorganic & medicinal chemistry letters Vol. 24; no. 13; pp. 2877 - 2880
• Main Authors: Johnson, Michael G, Liu, Jim, Li, An-Rong, Lengerich, Bettina van, Wang, Sophie, Medina, Julio C, Collins, Tassie L, Danao, Jay, Seitz, Lisa, Willee, Angela, D'Souza, Warren, Budelsky, Alison L, Fan, Peter W, Wong, Simon GW
• Format: Journal Article
• Language: English
• Published: 01.07.2014

Based on their structural similarity to previously described compound AMG 009, indole-phenyl acetic acids were proposed to be potent dual inhibitors of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2 or DP sub(2)) and prostanoid D receptor (DP or DP sub(1)). This series wa...