Structures of Exocyclic R,R- and S,S-N super(6),N super(6)-(2,3-Dihydroxy butan-1,4-diyl)-2'-Deoxyadenosine Adducts Induced by 1,2,3,4-Diepoxybutane

• Published in: Chemical research in toxicology Vol. 27; no. 5; pp. 805 - 817-805-817
• Main Authors: Kowal, Ewa A, Seneviratne, Uthpala, Wickramaratne, Susith, Doherty, Kathleen E, Cao, Xiangkun, Tretyakova, Natalia, Stone, Michael P
• Format: Journal Article
• Language: English
• Published: 19.05.2014

1,3-Butadiene (BD) is an industrial and environmental chemical present in urban air and cigarette smoke, and is classified as a human carcinogen. It is oxidized by cytochrome P450 to form 1,2,3,4-diepoxybutane (DEB); DEB bis-alkylates the N super(6) position of adenine in DNA. Two enantiomers of bis...