The M sub(r) 80,000 Common Forms of Neurophysin and Vasopressin From Bovine Neurohypophysis Have Corticotropin- and beta -Endorphin-Like Sequences and Liberate by Proteolysis Biologically Active Corticotropin

The authors have tested the hypothesis that the high M sub(r) forms common to both neurophysin and vasopressin detected in bovine neurohypophysis extracts might also contain the sequences of other known neuropeptides. The following evidence indicates that corticotropin- and beta -endorphin-like sequ...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 78; no. 10; pp. 6086 - 6090
Main Authors Lauber, M, Nicolas, P, Boussetta, H, Fahy, C, Beguin, P, Camier, M, Vaudary, H, Cohen, P
Format Journal Article
LanguageEnglish
Published 01.01.1981
Subjects
beta -endorphin
cattle
corticotropin
neurohypophysis
neurophysin
proteins
vasopressin
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Summary:The authors have tested the hypothesis that the high M sub(r) forms common to both neurophysin and vasopressin detected in bovine neurohypophysis extracts might also contain the sequences of other known neuropeptides. The following evidence indicates that corticotropin- and beta -endorphin-like sequences are associated with similar high M sub(r) forms and are included in these M sub(r) 80,000 molecules. The name neurohypophyseal "coenophorin" is proposed for this class of M sub(r) 80,000 polypeptides that might represent the common precursor store-house for a set of neuropeptides produced in the hypothalamo-neurophyseal tract.
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ISSN:0027-8424