21-( super(18)F)fluoro-16 alpha -ethyl-19-norprogesterone: Synthesis and target tissue selective uptake of a progestin receptor based radiotracer for positron emission tomography

• Published in: Journal of medicinal chemistry Vol. 31; no. 7; pp. 1360 - 1363
• Main Authors: Pomper, M G, Katzenellenbogen, JA, Welch, MJ, Brodack, J W, Mathias, C J
• Format: Journal Article
• Language: English
• Published: 01.01.1988

The authors have synthesized 21-( super(18)F)fluoro-16 alpha -ethyl-19-norprogesterone (FENP), a high affinity ligand for the progesterone receptor, labeled with the positron-emitting radionuclide fluorine-18. ( super(18)F)FENP demonstrates highly selective, receptor-mediated uptake by the uterus of...