Striped, bioactive Ce-TiO sub(2) materials with peroxynitrite-scavenging activity

• Published in: Journal of materials chemistry. B, Materials for biology and medicine Vol. 2; no. 7; pp. 834 - 845
• Main Authors: Gravina, ANoel, Ruso, Juan M, Laiuppa, Juan A, Santillan, Graciela E, Marco-Brown, Jose L, D'Elia, Noelia L, Messina, Paula V
• Format: Journal Article
• Language: English
• Published: 01.01.2014
• Subjects: Alignment
• ISSN: 2050-750X; 2050-7518
• DOI: 10.1039/c3tb21556c

Controlling aligned fiber micro-architectures to simulate the extracellular matrix for inducing important biological functions is a key challenge with regard to successful tissue regeneration. Here we present a bottom-up microemulsion-mediated strategy to obtain highly bioactive and biocompatible, striped Ce-TiO sub(2) nano-crystalline superstructures with ONOO super(-) scavenging activity. The employment of a bulkier organic ceria precursor in the material synthesis has several concurrent effects: (I) influencing the interfacial microemulsion droplet elasticity to create an aligned distribution of prismatic anatase nanoparticles causing the final lined morphology, (II) stabilizing the anatase active phase in a fine dispersed state and improving its resistance to the thermal anatase-rutile conversion, (III) indirectly favoring the rapid formation on the material surface of a hydroxyapatite layer composed of sphere-like globules of 3-5 mu m in diameter essential for bone-bonding, and finally (IV) accelerating the ONOO super(-) degradation into less harmful species NO sub(2) super(-) and O sub(2).