Secreted Proteins from the Helminth Fasciola hepatica Inhibit the Initiation of Autoreactive T Cell Responses and Prevent Diabetes in the NOD Mouse: e86289

• Published in: PloS one Vol. 9; no. 1
• Main Authors: Lund, Maria E, Hutchinson, Andrew T, Robinson, Mark W, Simpson, Ann M, Dalton, John P, Donnelly, Sheila
• Format: Journal Article
• Language: English
• Published: 01.01.2014
• Subjects: Fasciola hepatica

Infections with helminth parasites prevent/attenuate auto-inflammatory disease. Here we show that molecules secreted by a helminth parasite could prevent Type 1 Diabetes (T1D) in nonobese diabetic (NOD) mice. When delivered at 4 weeks of age (coincident with the initiation of autoimmunity), the excr...