Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl I2-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia

• Published in: Bioorganic & medicinal chemistry Vol. 20; no. 22; pp. 6598 - 6612
• Main Authors: Fushimi, Nobuhiko, Fujikura, Hideki, Shiohara, Hiroaki, Teranishi, Hirotaka, Shimizu, Kazuo, Yonekubo, Shigeru, Ohno, Kohsuke, Miyagi, Takashi, Itoh, Fumiaki, Shibazaki, Toshihide, Tomae, Masaki, Ishikawa-Takemura, Yukiko, Nakabayashi, Takeshi, Kamada, Noboru, Ozawa, Tomonaga, Kobayashi, Susumu, Isaji, Masayuki
• Format: Journal Article
• Language: English
• Published: 01.11.2012
• Subjects: Blood

Sodium glucose co-transporter 1 (SGLT1) plays a dominant role in the absorption of glucose in the gut and is considered a promising target in the development of treatments for postprandial hyperglycemia. A series of 4-benzyl-1H-pyrazol-3-yl I2-d-glucopyranoside derivatives have been synthesized, and...