Effects of Genetic Polymorphisms CYP1A1, GSTM1, GSTT1 and GSTP1 on Urinary 1-Hydroxypyrene Levels in Sugarcane Workers

Effects of genetic polymorphisms CYP1A1, GSTM1, GSTT1, and GSTP1 on urinary 1-hydroxypyrene levels in sugarcane workers are investigated. The results show that the 1-OHP levels are significantly higher in the exposed sugarcane workers than in the non-exposed workers. In an unvaried analysis, no infl...

Full description

Saved in:
Bibliographic Details
Published inThe Science of the total environment Vol. 370; no. 2; p. 380
Main Authors do Vale Bosso, Rosa Maria, Amorim, Lidia Maria Fonte, Andrade, Sandro Jose, Rossini, Ana, de Marchi, Mary Rosa Rodrigues, de Leon, Antonio Ponce, Carareto, Claudia Marcia Aparecida
Format Journal Article
LanguageEnglish
Published 01.11.2006
Online AccessGet full text

Cover

More Information
Summary:Effects of genetic polymorphisms CYP1A1, GSTM1, GSTT1, and GSTP1 on urinary 1-hydroxypyrene levels in sugarcane workers are investigated. The results show that the 1-OHP levels are significantly higher in the exposed sugarcane workers than in the non-exposed workers. In an unvaried analysis, no influence regarding the polymorphisms is observed. However, multivariate regression analysis shows that the CYP1A1*4 polymorphism in the exposed group, and age and the GSTP1 polymorphism in the non-exposed group significantly influences urinary 1-OHP extraction levels. It is found that the same group of sugarcane workers is significantly more exposed to PAHs during the harvesting period than during the non-harvesting period.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-1
ISSN:0048-9697