Effects of Genetic Polymorphisms CYP1A1, GSTM1, GSTT1 and GSTP1 on Urinary 1-Hydroxypyrene Levels in Sugarcane Workers
Effects of genetic polymorphisms CYP1A1, GSTM1, GSTT1, and GSTP1 on urinary 1-hydroxypyrene levels in sugarcane workers are investigated. The results show that the 1-OHP levels are significantly higher in the exposed sugarcane workers than in the non-exposed workers. In an unvaried analysis, no infl...
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Published in | The Science of the total environment Vol. 370; no. 2; p. 380 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.11.2006
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Online Access | Get full text |
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Summary: | Effects of genetic polymorphisms CYP1A1, GSTM1, GSTT1, and GSTP1 on urinary 1-hydroxypyrene levels in sugarcane workers are investigated. The results show that the 1-OHP levels are significantly higher in the exposed sugarcane workers than in the non-exposed workers. In an unvaried analysis, no influence regarding the polymorphisms is observed. However, multivariate regression analysis shows that the CYP1A1*4 polymorphism in the exposed group, and age and the GSTP1 polymorphism in the non-exposed group significantly influences urinary 1-OHP extraction levels. It is found that the same group of sugarcane workers is significantly more exposed to PAHs during the harvesting period than during the non-harvesting period. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-1 |
ISSN: | 0048-9697 |