Airway responses to aerosolized leukotriene D sub(4) (LTD sub(4)) in normal and Ascaris) reactor primates

• Published in: Prostaglandins Vol. 29; no. 2; pp. 313 - 322
• Main Authors: Johnson, H G, Stout, B K
• Format: Journal Article
• Language: English
• Published: 01.01.1985
• ISSN: 0090-6980

Normal and Ascaris reactor primates were compared for their bronchial pulmonary response to aerosolized leukotriene D sub(4) (LTD sub(4)). When 10 mu g/ml LTD sub(4) was aerosolized (total amount delivered to endotracheal tube was 1.0 mu g) into the lungs of 6 normal primates, a small increase in total lung resistance (R sub(L)) was noted. However, a larger effect was seen in compliance. Ascaris) reactors demonstrated a larger R sub(L) effect than normals with almost an identical Cdyn change. The results indicate that the LTD agonist action is partially mediated through histamine, primarily acting on lung resistance (large airways) and, in addition, may have a reflex atropine-sensitive component. The difference between the response of normal and reactor primates to LTD sub(4) is primarily a histamine-mediated large airway response.