PLGA nanoparticles loaded with the antileishmanial saponin [beta]-aescin: Factor influence study and in vitro efficacy evaluation

• Published in: International journal of pharmaceutics Vol. 420; no. 1; pp. 122 - 132
• Main Authors: Ven, HVan de, Vermeersch, M, Matheeussen, A, Vandervoort, J, Weyenberg, W, Apers, S, Cos, P, Maes, L, Ludwig, A
• Format: Journal Article
• Language: English
• Published: 25.11.2011
• Subjects: Leishmania infantum

Colloidal carriers are known to improve the therapeutic index of the conventional drugs in the treatment of visceral leishmaniasis (VL) by decreasing their toxicity whilst maintaining or increasing therapeutic efficacy. This paper describes the development of poly(d,l-lactide-co-glycolide) (PLGA) na...