Brain and Whole-Body Imaging of Nociceptin/Orphanin FQ Peptide Receptor in Humans Using the PET Ligand ^sup 11^C-NOP-1A

• Published in: The Journal of nuclear medicine (1978) Vol. 53; no. 3; p. 385
• Main Authors: Lohith, Talakad G, Zoghbi, Sami S, Morse, Cheryl L, Araneta, Maria F, Barth, Vanessa N, Goebl, Nancy A, Tauscher, Johannes T, Pike, Victor W, Innis, Robert B, Fujita, Masahiro
• Format: Journal Article
• Language: English
• Published: New York Society of Nuclear Medicine 01.03.2012
• Subjects: Blood-brain barrier; Brain; Drug dosages; Human subjects; Ligands; Peptides; Plasma

Nociceptin/orphanin FQ peptide (NOP) receptor is a new class of opioid receptor that may play a pathophysiologic role in anxiety and drug abuse and is a potential therapeutic target in these disorders. We previously developed a high-affinity PET ligand, ^sup 11^C-NOP-1A, which yielded promising resu...