Notch induces human T-cell receptor [gamma][delta]+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway

• Published in: Leukemia Vol. 26; no. 1; p. 127
• Main Authors: Van Coppernolle, S, Vanhee, S, Verstichel, G, Snauwaert, S, Van Der Spek, A, Velghe, I, Sinnesael, M, Heemskerk, M H, Taghon, T, Leclercq, G, Plum, J, Langerak, A W, Kerre, T, Vandekerckhove, B
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 01.01.2012
• Subjects: Blood & organ donations; Genotype & phenotype; Immunology; Leukemia; Mutation; Thymus gland; Netherlands; Belgium; United States > US; Germany

In wild-type mice, T-cell receptor (TCR) γδ(+) cells differentiate along a CD4 CD8 double-negative (DN) pathway whereas TCRα[beta](+) cells differentiate along the double-positive (DP) pathway. In the human postnatal thymus (PNT), DN, DP and single-positive (SP) TCRγδ(+) populations are present. Her...