Coupling factor 6-induced activation of ecto-F^sub 1^F^sub o^ complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice

• Published in: Diabetologia Vol. 55; no. 2; p. 520
• Main Authors: Osanai, T, Tanaka, M, Magota, K, Tomita, H, Okumura, K
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer Nature B.V 01.02.2012
• Subjects: Acidosis; Angiogenesis; Blood pressure; Cardiovascular disease; Diabetes; Glucose; Hypertension; Insulin resistance; Ischemia; Kinases; Mitochondria; Mortality; Musculoskeletal system; Peptides; Phosphorylation; Plasma; Public health; Transgenic animals

Despite advances in pharmacological treatments, diabetes with hypertension continues to be a major public health problem with high morbidity and mortality rates. We recently identified a circulating peptide coupling factor 6 (CF6), which binds to the plasma membrane ATP synthase (ecto-F^sub 1^F^sub...