A leaky mutation in CD3D differentially affects [alpha][Beta] and [gamma][delta] T cells and leads to a T[alpha][Beta]^sup -^T[gamma][delta]^sup +^B^sup +^NK^sup +^ human SCID

• Published in: The Journal of clinical investigation Vol. 121; no. 10; p. 3872
• Main Authors: Gil, Juana, Busto, Elena M, Garcillán, Beatriz, Chean, Carmen, García-Rodríguez, Maria Cruz, Díaz-Alderete, Andrea, Navarro, Joaquín, Reiné, Jesús, Mencía, Angeles, Gurbindo, Dolores, Beléndez, Cristina, Gordillo, Isabel, Duchniewicz, Marlena, Höhne, Kerstin, García-Sánchez, Félix, Fernández-Cruz, Eduardo, López-Granados, Eduardo, Schamel, Wolfgang W A, Moreno-Pelayo, Miguel A, Recio, María J, Regueiro, José R
• Format: Journal Article
• Language: English
• Published: Ann Arbor American Society for Clinical Investigation 01.10.2011
• Subjects: Biomedical research

T cells recognize antigens via their cell surface TCR and are classified as either α[beta] or γδ depending on the variable chains in their TCR, α and [beta] or γ and δ, respectively. Both α[beta] and γδ TCRs also contain several invariant chains, including CD3δ, which support surface TCR expression...