Prostaglandin E^sub 2^ Inhibits Human Lung Fibroblast Chemotaxis through Disparate Actions on Different E-Prostanoid Receptors

• Published in: American journal of respiratory cell and molecular biology Vol. 44; no. 1; p. 99
• Main Authors: Li, Ying-Ji, Wang, Xing-Qi, Sato, Tadashi, Kanaji, Nobuhiro, Nakanishi, Masanori, Kim, Miok, Michalski, Joel, Nelson, Amy J, Sun, Jian-Hong, Farid, Maha, Basma, Hesham, Patil, Amol, Toews, Myron L, Liu, Xiangde, Rennard, Stephen I
• Format: Journal Article
• Language: English
• Published: New York American Thoracic Society 01.01.2011

The migration of fibroblasts is believed to play a key role in both normal wound repair and abnormal tissue remodeling. Prostaglandin E (PGE)(2), a mediator that can inhibit many fibroblast functions including chemotaxis, was reported to be mediated by the E-prostanoid (EP) receptor EP2. PGE(2), how...