IgE-Dependent and IgE-Independent Stimulation of Human Basophils Increases the Presence of Immature Fc[epsilon]RI[alpha] by Reversing Degradative Pathways

• Published in: International archives of allergy and immunology Vol. 154; no. 1; p. 15
• Main Authors: Zaidi, Asifa K, Macglashan, Jr, Donald
• Format: Journal Article
• Language: English
• Published: Basel S. Karger AG 01.12.2010
• Subjects: Immune system; Immunoglobulins; Leukocytes

Background: Expression of the high-affinity IgE receptor, FcεRI, on mast cells and basophils has previously been shown to be sensitive to the presence of IgE or cytokines. The current study examined whether stimulation of human basophils resulted in a change in the expression of FcεRI. Methods: Ch...