The Transcription Factor Rfx3 Regulates [Beta]-Cell Differentiation, Function, and Glucokinase Expression

• Published in: Diabetes (New York, N.Y.) Vol. 59; no. 7; p. 1674
• Main Authors: Ait-Lounis, Aouatef, Bonal, Claire, Seguín-Estévez, Queralt, Schmid, Christoph D, Bucher, Philipp, Herrera, Pedro L, Durand, Bénédicte, Meda, Paolo, Reith, Walter
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.07.2010
• Subjects: Cells; Diabetes; Experiments; Glucagon; Glucose; Insulin; Pancreas; Research design; Transcription factors

Pancreatic islets of perinatal mice lacking the transcription factor Rfx3 exhibit a marked reduction in insulin-producing beta-cells. The objective of this work was to unravel the cellular and molecular mechanisms underlying this deficiency. Immunofluorescence studies and quantitative RT-PCR experim...