Deep Learning with Evolutionary Scale Modeling to discover Antibiotic-Resistance Drug against Klebsiella Pneumoniae

• Published in: bioRxiv
• Main Authors: Jin, Linxiao, Lei, Zhihao, Lin, Peng, Ma, Cong, Zhang, Wen, Zhou, Jiali, Meng, Sijun, Jiang, Zhenghua, Bu, Yemei, Xu, Yingfan, Nijun Wei, Hsu, Tsehao, Qin, Glen, Qiu, Hesong
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 11.11.2024
• Subjects: Antibiotic resistance; Antibiotics; Clinical trials; Deep learning; Drug development; Drug discovery

The development of effective antibiotics is crucial in combating antibiotic-resistant pathogens such as Klebsiella pneumoniae (KP). This study utilizes deep learning, specifically Evolutionary Scale Modeling (ESM), to identify potential drug candidates. By analyzing molecular similarities between kn...