2064-LB: Novel Amylin and Calcitonin Receptor Coagonists Reduce Food Intake and Body Weight in Rodents

• Published in: Diabetes (New York, N.Y.) Vol. 73; p. 1
• Main Author: Yagiz, Kader
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2024
• Subjects: Agonists; Amylin; Animal models; Appetite; Arrestin; Body weight; Diabetes mellitus; Food; Food intake; Food selection; Metabolic disorders; Metabolic rate; Metabolism; Obesity; Pharmacokinetics; Receptor mechanisms

Amylin analogs have been shown to significantly reduced body weight and dosage of insulin. Dual amylin and calcitonin receptor agonists (DACRAs) are the most potent amylin receptor agonists. We developed a series of novel long-acting amylin agonists to assess the potency on both calcitonin (CTR) and...