1887-LB: Effect of Dorzagliatin, a Dual-Acting Glucokinase Activator, on Insulin and Glucagon Secretion in Impaired and Normal Glucose Tolerance

• Published in: Diabetes (New York, N.Y.) Vol. 73; p. 1
• Main Authors: Bai, Zhengli, Wang, Ke, Yau, Tiffany Tse Ling, Poon, Emily W, Luk, Andrea, Ma, Ronald C, Kong, Alice P, Chow, Elaine, Chen, Li, Chan, Juliana C
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2024
• Subjects: Allosteric properties; Antidiabetics; Beta cells; Diabetes mellitus (non-insulin dependent); Glucagon; Glucokinase; Glucose tolerance; Insulin; Insulin secretion; Peptides; Placebos

Dorzagliatin is a novel dual-acting allosteric activator of hepatic and beta-cell glucokinase (GCK). Dorzagliatin improved second-phase insulin secretion in type 2 diabetes and heterozygous carriers of GCK mutations. We investigated the effects of dorzagliatin on insulin secretion and glucagon suppr...