Protein overabundance is driven by growth robustness

• Published in: arXiv.org
• Main Authors: Choi, H James, Lo, Teresa W, Cutler, Kevin J, Huang, Dean, W Ryan Will, Wiggins, Paul A
• Format: Paper
• Language: English
• Published: Ithaca Cornell University Library, arXiv.org 21.08.2024
• Subjects: Gene expression; Predictions; Proteins; Robustness; Tradeoffs

Protein expression levels optimize cell fitness: Too low an expression level of essential proteins will slow growth by compromising essential processes; whereas overexpression slows growth by increasing the metabolic load. This trade-off naively predicts that cells maximize their fitness by sufficie...