Gene map of the extended humanMHC

• Published in: Nature reviews. Genetics Vol. 5; no. 12; pp. 889 - 899
• Main Authors: Horton, Roger, Wilming, Laurens, Rand, Vikki, Lovering, Ruth C, Bruford, Elspeth A, Khodiyar, Varsha K, Lush, Michael J, Povey, Sue, Talbot, C. Conover, Wright, Mathew W, Wain, Hester M, Trowsdale, John, Ziegler, Andreas, Beck, Stephan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 01.12.2004
• Subjects: Autoimmune diseases; Autoimmunity; Disease; Gene clusters; Gene duplication; Gene loci; Gene polymorphism; Genomes; Genomic analysis; Histones; Immune response; Innate immunity; Major histocompatibility complex; Medical research; Nucleotide sequence; Research hot spots; tRNA

Key PointsThe gene map for the extended major histocompatibility complex (xMHC) comprises 421 loci (excluding RNA genes) in a sequence length of 7.6 Mb — extending the previous gene map of the classical MHC, which was 3.6 Mb long and contained 224 loci.All 421 xMHC loci have been assigned definitive...