Transposon mutagenesis screen in Klebsiella pneumoniae identifies genetic determinants required for growth in human urine and serum

• Published in: bioRxiv
• Main Authors: Gray, Jessica, Von Vergel L Torres, Emily Ca Goodall, Mckeand, Samantha A, Scales, Danielle, Collins, Christy, Wetherall, Laura, Zheng, Jie Lian, Bryant, Jack A, Milner, Mathew T, Dunne, Karl, Icke, Christopher, Rooke, Jessica, Schneiders, Thamarai, Lund, Peter A, Cunningham, Adam F, Cole, Jeffrey A, Henderson, Ian R
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 07.02.2024
• Subjects: Antimicrobial agents; Drug resistance; Genomes; Klebsiella pneumoniae; Multidrug resistance; Public health; Transposon mutagenesis; Transposons; Urine

Klebsiella pneumoniae is a global public health concern due to the rising myriad of hypervirulent and multi-drug resistant clones both alarmingly associated with high mortality. The molecular microbial genetics underpinning these recalcitrant K. pneumoniae infections is unclear, coupled with the eme...