Design, Synthesis, in Vitro and Molecular Dynamic Study of Antifungal Activity of the Alcoholic Extract of Sygysium aromaticum in Comparison to Some New Sulphonamide Derivatives

• Published in: Azerbaijan Pharmaceutical and Pharmacotherapy Journal Vol. 22; no. 1; pp. 45 - 52
• Main Authors: Humadi, Suhad Sami, Awad, Samir Mohamed, El-Shehery, Mohamed Fathy, El-Rashedy, Ahmed Abd Elkader, Mansour, Yara Essam, Hassan, Saif M
• Format: Journal Article
• Language: English
• Published: Baku Azerbaijan Medical University 01.01.2023
• Subjects: Antifungal agents; Flowers & plants; Fungi; Fungicides; Pesticides; R&D; Research & development; Simulation; Egypt; Indonesia

Five synthetic 2-Thiouracil-5-sulphonamides were evaluated as antifungal agents against the same fungal isolates. Their synergistic effect with clove extract was assessed in an attempt to formulate a potential combination therapy for the future. The goal was to evaluate whether thiouracil derivative...