Immunohistochemical Cathepsin-D Expression In Breast Carcinoma Correlation With Prognostic Factors And Survival
[LANGUAGE= "English"] Purpose: Breast cancer is an increasingly important cause of illness and death among women. In recent years, several prognostic determinents of breast cancer have been identified, including Cathepsin-D (CD).Material and methods: CD protein expression was analysed immu...
Saved in:
Published in | Journal of Clinical Practice & Research Vol. 26; no. 4; p. 178 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | Turkish |
Published |
Istanbul
Kare Publishing
01.01.2004
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | [LANGUAGE= "English"] Purpose: Breast cancer is an increasingly important cause of illness and death among women. In recent years, several prognostic determinents of breast cancer have been identified, including Cathepsin-D (CD).Material and methods: CD protein expression was analysed immunohistochemically in tumor specimens of 64 breast cancer patients.Results: CD expression was determined in 68.7% of the cases, and immunoreaction was strong in 45.3% of the cases. There was a significant correlation between stage (p=0.01) and c-erbB-2 immunorectivity (p=0.017). After a median follow up of 33 months, CD positivity showed significant correlation with disease free survival (p=0.011) but not with overall survival.Conclusions: CD expression is related to recurrence and metastatic potential of breast cancer. In addition, CD expression may be acquired in the preinvasive stage of the carcinoma, since there was CD immunoreactivity in adjacent in-situ ductal carcinoma areas of strongly immunoreactive invasive carcinomas. |
---|---|
AbstractList | [LANGUAGE= "English"] Purpose: Breast cancer is an increasingly important cause of illness and death among women. In recent years, several prognostic determinents of breast cancer have been identified, including Cathepsin-D (CD).Material and methods: CD protein expression was analysed immunohistochemically in tumor specimens of 64 breast cancer patients.Results: CD expression was determined in 68.7% of the cases, and immunoreaction was strong in 45.3% of the cases. There was a significant correlation between stage (p=0.01) and c-erbB-2 immunorectivity (p=0.017). After a median follow up of 33 months, CD positivity showed significant correlation with disease free survival (p=0.011) but not with overall survival.Conclusions: CD expression is related to recurrence and metastatic potential of breast cancer. In addition, CD expression may be acquired in the preinvasive stage of the carcinoma, since there was CD immunoreactivity in adjacent in-situ ductal carcinoma areas of strongly immunoreactive invasive carcinomas. |
Author | Özkan, Metin Küçük, Can Soyuer, Serdar Öztürk, Figen Akgün, Hülya Deniz, Kemal Canöz, Özlem |
Author_xml | – sequence: 1 givenname: Özlem surname: Canöz fullname: Canöz, Özlem – sequence: 2 givenname: Serdar surname: Soyuer fullname: Soyuer, Serdar – sequence: 3 givenname: Hülya surname: Akgün fullname: Akgün, Hülya – sequence: 4 givenname: Kemal surname: Deniz fullname: Deniz, Kemal – sequence: 5 givenname: Metin surname: Özkan fullname: Özkan, Metin – sequence: 6 givenname: Can surname: Küçük fullname: Küçük, Can – sequence: 7 givenname: Figen surname: Öztürk fullname: Öztürk, Figen |
BookMark | eNqNys9qwkAQgPFFLPinvsNAz4HtNpHsUdNIvRUUepRlXc1KMhNnNqGPXwt9gJ6-w-9bqCkShomaG1vqzLwW65laidy01sbmRWHLuaJ91w1ITZREvgld9K6FyqUm9BIxe4f6u-cgEglhj7Dl4CQ9BvYRqXNQEXNoXfr1r5ga-GS6IkmKHnbOJ2KBDZ7hMPAYR9c-q6eLayWs_rpUL7v6WH1kPdN9CJJONxoYH3Qypc2tyXWu3_53_QCHsky4 |
ContentType | Journal Article |
Copyright | 2004. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
Copyright_xml | – notice: 2004. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
DBID | 3V. 7X7 7XB 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S PIMPY PQEST PQQKQ PQUKI PRINS |
DatabaseName | ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China |
DatabaseTitle | Publicly Available Content Database ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete Health Research Premium Collection ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest One Academic ProQuest Central (Alumni) |
DatabaseTitleList | Publicly Available Content Database |
Database_xml | – sequence: 1 dbid: 7X7 name: Health & Medical Collection url: https://search.proquest.com/healthcomplete sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
EISSN | 2980-2156 |
GroupedDBID | 3V. 7X7 7XB 8FI 8FJ 8FK ABUWG AFKRA ALMA_UNASSIGNED_HOLDINGS AZQEC BENPR CCPQU DWQXO FYUFA HMCUK K9. PIMPY PQEST PQQKQ PQUKI PRINS UKHRP |
ID | FETCH-proquest_journals_28949240403 |
IEDL.DBID | BENPR |
IngestDate | Thu Oct 10 17:18:16 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Language | Turkish |
LinkModel | DirectLink |
MergedId | FETCHMERGED-proquest_journals_28949240403 |
OpenAccessLink | https://www.proquest.com/docview/2894924040?pq-origsite=%requestingapplication% |
PQID | 2894924040 |
PQPubID | 5083802 |
ParticipantIDs | proquest_journals_2894924040 |
PublicationCentury | 2000 |
PublicationDate | 20040101 |
PublicationDateYYYYMMDD | 2004-01-01 |
PublicationDate_xml | – month: 01 year: 2004 text: 20040101 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | Istanbul |
PublicationPlace_xml | – name: Istanbul |
PublicationTitle | Journal of Clinical Practice & Research |
PublicationYear | 2004 |
Publisher | Kare Publishing |
Publisher_xml | – name: Kare Publishing |
SSID | ssj0002945598 |
Score | 3.1204429 |
Snippet | [LANGUAGE= "English"] Purpose: Breast cancer is an increasingly important cause of illness and death among women. In recent years, several prognostic... |
SourceID | proquest |
SourceType | Aggregation Database |
StartPage | 178 |
SubjectTerms | Breast cancer Medical prognosis Metastasis Protein expression |
Title | Immunohistochemical Cathepsin-D Expression In Breast Carcinoma Correlation With Prognostic Factors And Survival |
URI | https://www.proquest.com/docview/2894924040 |
Volume | 26 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV07T8MwED7RdmFBIEA8SnUSrBY0cV4TakuiFomq4iGyVYkbiw7YJU0lfj7nxIUBqbMjO7bPn33n7_wB3AR3WSCizGeeJzPGvVCwXDgRLTwpCu7nfV6njz1N_fEbf0y91Abc1pZWucXEGqgXWpgY-S05Bpx8BbK5-9UXM6pR5nbVSmi0oOP0ubmm7Qzj6ez5N8riRNy8QP4PaOvdIzmEA3vsw0EzT0ewV5XHoCcmOUPXT_4Km7iPdUreijx49oDxt6WpKpwoHBr-eEUflGKp9GeGI6Os0XDZ8H1ZfeCs1IY3R21g0ujo4EAt8GVDeEAWdQLXSfw6GrPtX86tJa3nf_12T6GttCrOALlwBSGmFI6MuAjd3DUqkIUXSTq_hAU_h-6umi52F1_CfsNPMYGGLrSrclNc0dZb5T1oBWnQs6P8A_Q4kMI |
link.rule.ids | 315,786,790,12083,21416,31752,33777,43343,43838 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3PT4MwFH5RdtCL0ajxx9SX6LVRR2FwMtuEgG5k0Rl3I9BB3EE6GUv8832FTg8mO7cphT6-9r1-730AN927pCvcxGaWlSeMW45gqei49OPlIuN2es_r9LFRZAdv_GlqTXXAbalplWtMrIF6JoWKkd-SY8DJVyCbe1h8MaUapW5XtYTGNrRUyU3HgFbfi8Yvv1GWjstVBfJ_QFvvHv4-7OljH_aadTqArao8BBmq5AxZl_wVOnEf65S8BXnw7BG9b01TLTAssK_44xV1KMW8kJ8JDpSyRsNlw_d59YHjUireHD0D_UZHB3vFDF9XhAdkUUdw7XuTQcDWs4y1JS3jv_c2j8EoZJGdAHJhCkLMXHRylwvHTE2lAplZbk7nFyfjp9DeNNLZ5uYr2Akmo2E8DKPnc9htuCoq6NAGoypX2QVtw1V6qb_1D4TsktE |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Immunohistochemical+Cathepsin-D+Expression+In+Breast+Carcinoma+Correlation+With+Prognostic+Factors+And+Survival&rft.jtitle=Journal+of+Clinical+Practice+%26+Research&rft.au=Can%C3%B6z%2C+%C3%96zlem&rft.au=Soyuer%2C+Serdar&rft.au=Akg%C3%BCn%2C+H%C3%BClya&rft.au=Deniz%2C+Kemal&rft.date=2004-01-01&rft.pub=Kare+Publishing&rft.eissn=2980-2156&rft.volume=26&rft.issue=4&rft.spage=178 |