O10 TNF signalling associated with high risk compared to low risk disease in primary biliary cholangitis: a transcriptomic analysis of peripheral immune cells

• Published in: Gut Vol. 72; no. Suppl 3; pp. A7 - A8
• Main Authors: Mulcahy, Victoria, Jose-Ezequiel, Martin, Hails, Janeane, Sandford, Richard, Jones, David, Hirschfield, Gideon, Mells, George
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.09.2023
• Subjects: Bile ducts; CD4 antigen; CD8 antigen; Cholangitis; Cirrhosis; Factor analysis; Genes; Inflammatory diseases; Liver diseases; Lymphocytes; Lymphocytes B; Lymphocytes T; Monocytes; Peripheral blood mononuclear cells; Risk groups; Signal transduction; Transcriptomics; Ursodeoxycholic acid

Primary biliary cholangitis (PBC) is an immune-mediated inflammatory disorder of the interlobular bile ducts which leads in many cases to cirrhosis. In patients with PBC, inadequate biochemical response to first-line treatment with ursodeoxycholic acid (UDCA) identifies those at high risk of progres...