Dr. Danuta Jantas Associate Editor, Frontiers in Aging Neuroscience Implication of the cooking oil-peroxidation product ‘hydroxynonenal’ for Alzheimer’s disease

• Published in: Frontiers in aging neuroscience
• Main Authors: Yamashima, Tetsumori, Seike, Takuya, Mochly-Rosen, Daria, Chen, Che-Hong, Kikuchi, Mitsuru, Mizukoshi, Eishiro
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 25.08.2023
• Subjects: Aldehyde dehydrogenase; Alzheimer's disease; Apoptosis; Autophagy; Brain injury; Brain research; Calpain; Cell death; Cognition & reasoning; Dementia; Dementia disorders; Detoxification; Fatty acids; Hsp70 protein; Hypotheses; Ischemia; Linoleic acid; Lipid peroxidation; Lipids; Molecular modelling; Nervous system; Neurodegeneration; Neurodegenerative diseases; Oxidative stress; Pathology; Peptides; Proteins; Toxicity; β-Amyloid

Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that reduces cell injuries via detoxification of lipid-peroxidation product, 4-hydroxy-2-nonenal (hydroxynonenal). It is generated exogenously via deep-frying of linoleic acid-rich cooking oils and/or endogenously via oxidation of fatty acid...