POS0134 LEARNING FROM LONGITUDINAL DATA IN CHILDHOOD ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: WHICH BIOMARKERS HAVE PREDICTIVE VALUE FOR ENDOTHELIAL INVOLVEMENT?

• Published in: Annals of the rheumatic diseases Vol. 82; no. Suppl 1; pp. 286 - 287
• Main Authors: Bergkamp, S, Bergkamp, N, Wahadat, M J, Gruppen, M, A Nassar-Sheikh Rashid, Kuijpers, T, Tas, S, Smit, M, Kamphuis, S, J M Van den Berg, D Schonenberg-Meinema
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.06.2023
• Subjects: Angiogenesis; Angiopoietin; Arteriosclerosis; Arthritis; Atherosclerosis; Biomarkers; Cardiovascular diseases; Children; CXCL10 protein; CXCL12 protein; E-selectin; Endothelial cells; Endothelium; Intercellular adhesion molecule 1; IP-10 protein; Lupus; Monocyte chemoattractant protein 1; P-selectin; Patients; Pentraxins; Risk factors; SDF-1 protein; Serum levels; Systemic lupus erythematosus; Thrombomodulin; Vascular cell adhesion molecule 1; Vascular endothelial growth factor

BackgroundIn (childhood-onset) systemic lupus erythematosus ((c)SLE), patients have an increased risk of developing premature atherosclerosis [1]. The pathophysiological mechanisms for this atherosclerosis are not completely understood. Besides traditional risk factors, the endothelium plays a major...