Assessment of prophylactic use of oral micronized progesterone in prevention of preterm labour in high risk pregnancy

• Published in: Journal of Advanced Medical and Dental Sciences Research Vol. 11; no. 2; pp. 21 - 26
• Main Authors: Rathore, Kiran, Qureshi, Shazi
• Format: Journal Article
• Language: English
• Published: Amritsar Journal of Advanced Medical and Dental Sciences Research (JAMDSR) 01.02.2023
• Subjects: Apgar score; Birth weight; Epigenetics; Gestational age; Morbidity; Neonates; Pregnancy; Pregnancy complications; Premature birth; Prevention; Progesterone; Risk groups; Risk reduction; Socioeconomic factors
• DOI: 10.21276/jamdsr

Objective: To assess the effect of prophylactic use of oral micronized progesterone (OMP) in prevention of preterm labour(PTL) in high risk pregnancy. Methods: this present case control study was conducted at OBGY Department 120 women with at least one PTB who received 100 mg of OMP or no drug twice a day from recruitment (18-24 weeks) until 36 weeks or delivery. Results: PTB occurred in 29 women in the OMP group (n= 60) compared with 60 in the control group (n= 60, P = 0.002). Mean gestational age at delivery was higher in the OMP group (36.1 vs 34.0 weeks, P b 0.001). Fewer preterm births occurred between 28 and 31 weeks plus 6 days in the OMP group (RR 0.20; 95% CI, 0.05 -0.73, P b 0.001). Neonatal age at delivery (34 vs 32 weeks, P b 0.001), birth weight (2400 vs 1890 g, P b 0.001), NICU stay (N 24 h, P b 0.001), and Apgar scores (P b 0.001) were more favorable in the OMP group, and fewer neonatal deaths occurred (3 vs 7, P = 0.190). Conclusion: In high risk patients, OMP decreased the risk of PTB between 28 and 31 weeks plus 6 days, NICU admissions, and neonatal morbidity and mortality.