An alpaca-derived nanobody neutralizes the SARS-CoV-2 omicron variant

• Published in: bioRxiv
• Main Authors: Modhiran, Naphak, Lauer, Simon Malte, Amarilla, Alberto A, Hewins, Peter, Sara Irene Lopes Van Den Broek, Yu Shang Low, Thakur, Nazia, Liang, Benjamin, Guillermo Valenzuela Nieto, Jung, James, Paramitha, Devina, Isaacs, Ariel, De Sng, Julian, Song, David, Jorgensen, Jesper, Yorka Cheuquemilla, Burger, Jorg, Ida Vang Andersen, Himelreichs, Johanna, Jara, Ronald, Macloughlin, Ronan, Miranda-Chacon, Zaray, Chana-Cuevas, Pedro, Kramer, Vasko, Christian Mt Spahn, Mielke, Thorsten, Khromykh, Alexander A, Munro, Trent, Jones, Martina, Young, Paul R, Chappell, Keith, Bailey, Dalan, Kjaer, Andreas, Herth, Matthias Manfred, Jurado, Kellie Ann, Schwefel, David, Rojas-Fernandez, Alejandro, Watterson, Daniel
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 27.12.2022
• Subjects: Epitopes; Inhalation; Nanobodies; Severe acute respiratory syndrome coronavirus 2; Spike protein

The SARS-CoV2 Omicron variant sub-lineages spread rapidly through the world, mostly due to their immune-evasive properties. This has put a significant part of the population at risk for severe disease and underscores the need for anti-SARS-CoV-2 agents that are effective against emergent strains in...