Transient Body Fluid Accumulation and Enhanced NKCC2 Expression in Gerbils with Brain Infarction

• Published in: Nephron Vol. 103; no. 1; p. p25
• Main Authors: Ejima, Yutaka, Nakamura, Yohsuke, Michimata, Mari, Hatano, Ryo, Kazama, Itsuro, Sanada, Satoru, Arata, Tomohiro, Suzuki, Michiko, Miyama, Noriyuki, Sato, Akira, Satomi, Susumu, Fushiya, Shinji, Sasaki, Sei, Matsubara, Mitsunobu
• Format: Journal Article
• Language: English
• Published: Basel S. Karger AG 01.04.2006

Background: Enhanced expression of a kidney-specific sodium co-transporter (NKCC2: Na-K-2Cl co-transporter) in the thick ascending limb of Henle has been identified in rat models of congestive heart failure and liver cirrhosis, suggesting that high NKCC2 expression underlies edema formation. An incr...