Multi-drug resistant E. coli displace commensal E. coli from the intestinal tract, a trait associated with elevated levels of genetic diversity in carbohydrate metabolism genes

• Published in: bioRxiv
• Main Authors: Connor, Christopher, Zucoloto, Amanda, Yu, Ian Ling, Corander, Jukka, Mcdonald, Braedon, Mcnally, Alan
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 25.11.2022
• Subjects: Antibiotics; Antimicrobial resistance; Carbohydrate metabolism; Colonization; Digestive system; Drug resistance; E coli; Evolution; Gastrointestinal tract; Genetic diversity; Genomes; Gnotobiotic; Infections; Intestine; Metabolism; Multidrug resistance; Phylogeny; Urinary tract

Extra-intestinal pathogenic E. coli (ExPEC) can cause a variety of infections outside of the intestine and are a major causative agent of urinary tract infections. Treatment of these infections is increasingly frustrated by antimicrobial resistance (AMR) diminishing the number of effective therapies...