MLKL deficiency protects against low-grade, sterile inflammation in aged mice

• Published in: bioRxiv
• Main Authors: Tovey, Emma C, Garnish, Sarah E, Day, Jessica, Anderton, Holly, Chiou, Shene, Hempel, Anne, Hall, Cathrine, Patel, Komal, Gangatirkar, Pradnya, Connie Sn Li Wai Suen, Garnham, Alexandra, Kueh, Andrew J, Nachbur, Ueli, Samson, Andre L, Murphy, James M, Hildebrand, Joanne M
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 17.10.2022
• Subjects: Aging; Cell death; Immune system; Inflammation; Lymphocytes; Necroptosis; Phenotypes

MLKL and RIPK3 are the core signaling proteins of the inflammatory cell death pathway, necroptosis, which is a known mediator and modifier of human disease. Necroptosis has been implicated in the progression of disease in almost every physiological system and recent reports suggest a role for necrop...