DNA methyltransferase inhibition induces dynamic gene expression changes in lung CD4+ T cells of neonatal mice with E. coli pneumonia

• Published in: bioRxiv
• Main Authors: Michki, Nigel S, Ndeh, Roland, Helmin, Kathryn A, Singer, Benjamin D, Mcgrath-Morrow, Sharon A
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 01.10.2022
• Subjects: 5-aza-2'-deoxycytidine; Bronchopulmonary infection; CD4 antigen; Demethylation; DNA fingerprinting; DNA methylation; DNA methyltransferase; E coli; Epigenetics; Gene expression; Genomes; Interferon; Juveniles; Lungs; Lymphocytes; Lymphocytes T; Minors; Morbidity; Neonates; United States > US

Introduction: Bacterial pulmonary infections are a major cause of morbidity and mortality in neonates, with less severity in older children. Previous studies demonstrated that the DNA of CD4+ T cells in the mouse lung, whose primary responsibility is to coordinate the immune response foreign pathoge...