Cell type-specific prediction of 3D chromatin architecture

• Published in: bioRxiv
• Main Authors: Tan, Jimin, Rodriguez-Hernaez, Javier, Sakellaropoulos, Theodore, Boccalatte, Francesco, Aifantis, Iannis, Skok, Jane, Fenyo, David, Xia, Bo, Tsirigos, Aristotelis
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 07.03.2022
• Subjects: Chromatin; Gene expression; Genomes; Neural networks; Nucleotide sequence

The mammalian genome is spatially organized in the nucleus to enable cell type-specific gene expression. Investigating how chromatin architecture determines this specificity remains a big challenge. Methods for measuring the 3D chromatin architecture, such as Hi-C, are costly and bear strong technic...