Restoring the guardian of the genome
The unmutated, or wild-type, version of the gene, which was cloned from humans and mice in the 1980s, exerted the exact opposite effect: the gene acted as a potent inhibitor of tumorigenesis (S. J. Baker et al. Environmental stress, abnormal metabolic activity, genetic damage and advanced ageing can...
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| Published in | Nature (London) Vol. 603; no. 7899; p. S1 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group
03.03.2022
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The unmutated, or wild-type, version of the gene, which was cloned from humans and mice in the 1980s, exerted the exact opposite effect: the gene acted as a potent inhibitor of tumorigenesis (S. J. Baker et al. Environmental stress, abnormal metabolic activity, genetic damage and advanced ageing can all trigger the protein's activation, enabling p53 to directly regulate the expression of hundreds of genes to initiate an appropriate response. Cell Death Differ. 25, 154-160; 2018), and nearly 90% of people born with such mutations - a rare hereditary condition known as Li-Fraumeni Syndrome - will develop cancer in their lifetime. |
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| AbstractList | The unmutated, or wild-type, version of the gene, which was cloned from humans and mice in the 1980s, exerted the exact opposite effect: the gene acted as a potent inhibitor of tumorigenesis (S. J. Baker et al. Environmental stress, abnormal metabolic activity, genetic damage and advanced ageing can all trigger the protein's activation, enabling p53 to directly regulate the expression of hundreds of genes to initiate an appropriate response. Cell Death Differ. 25, 154-160; 2018), and nearly 90% of people born with such mutations - a rare hereditary condition known as Li-Fraumeni Syndrome - will develop cancer in their lifetime. |
| Author | Eisenstein, Michael |
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| DOI | 10.1038/d41586-022-00565-x |
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| SubjectTerms | Aging Cancer Cell death Chromosome aberrations Cloning Environmental stress Gene expression Genomes Li-Fraumeni syndrome Molecular weight Mutation p53 Protein Proteins Tumorigenesis Tumors |
| Title | Restoring the guardian of the genome |
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